Recombinant Antigens for IVD Infectious Diseases
Our products are mainly recombinant antigens used for in vitro diagnostic of human and animal infectious diseases. We can also offer you our biotinylated recombinant antigens in order to get a site-oriented immobilization in plates, to develop ECL experiments, assays of protein arrays and much more.
Classification of the products as Infectious Diseases Markers according to the International Classification of Infectious Diseases (ICD-10):
- Leptospirosis: is considered the most globally widespread zoonotic illness, caused by the pathogenic species of the genus Leptospira. The most consistent pathologic finding in leptospirosis is vasculitis of capillaries manifested by endothelial edema, necrosis, and lymphocytic infiltration. Wildlife and domestic animals can serve as reservoirs for multiple pathogenic serovars. Recombinant antigen LipL32.
- Borreliosis: Lyme disease is a multisystemic infectious disease and the most commonly reported tick-borne infection in the United States and is also endemic in Europe and parts of Asia. It is caused by bacteria of the Borrelia burgdorferi species complex (Borrelia burgdorferi sensu lato: Borrelia burgdorferi sensu stricto, Borrelia afzelii and Borrelia garinii). The reservoirs for this spirochete are the white-footed mouse and the white-tailed deer. Transmission is accomplished by the bite of infected deer ticks. Contact with the tick usually occurs in areas of brush and tall grass. Lyme disease can affect different body systems, such as the nervous system, joints, skin, and heart. Recombinant antigens: ospC, p14.
- Other bacterial infections
- Bacterial meningitis: is a serious infection of the fluid in the spinal cord and the fluid that surrounds the brain. Meningitis is usually caused by an infection with a virus or a bacterium. Knowing whether meningitis is caused by a virus or a bacterium is important because of differences in the seriousness of the illness and the treatment needed. Bacterial meningitis is much more serious. It can cause severe disease that can result in brain damage and even death. It is most commonly caused by one of three types of bacteria: Haemophilus influenzae type b, Neisseria meningitidis (meningococcal meningitis), and Streptococcus pneumoniae bacteria (pneumococcal meningitis) Recombinant antigens: ompP2 from Haemophilus influenzae, opa from Neisseria meningitidis.
- Typhoide Fever: this infection, also known simply as typhoid,is a common worldwide bacterial disease, transmitted by the ingestion of food or water contaminated with the feces of an infected person, which contain the bacterium Salmonella typhi. This infection is a major cause of morbidity and mortality worldwide, causing 21 million illnesses and 200,000 deaths annually. Recombinant antigen pagC.
- Sexually Transmitted Diseases:
- Syphilis: is a sexually transmitted disease caused by the spirochetal bacteria Treponema pallidum. Syphilis can present itself in one of four different stages: primary, secondary, latent, and tertiary. It may also be transmitted from mother to fetus during pregnancy or at birth resulting in congenital syphilis. It has been referred to as the "great imitator of skin diseases" due to its varied presentations. It often does not cause any symptoms in its early stages, but if left untreated, it can progress to affect the entire body. Recombinant antigens: Tpp17, Tpp15, Tpp47.
- Infectious diseases transmitted by espiroquetas, chlamydias and rickettsias
- Viral diseases of the Central Nervous System
- Arthropod-Borne Viral Diseases and Viral Hemorrhagic Fever:
- Dengue: viruses transmitted by the mosquito Aedes aegypti and Aedes albopictus which are widely spread throughout the tropical and subtropical areas of the world. There are four known distinct serotypes (DEN1, DEN2, DEN3 and DEN4). If the patient is infected by a different serotype repeatedly, a more severe disease dengue hemorrhagic fever or dengue shock syndrome is more likely to occur. Dengue is considered to be the most important arthropod borne viral disease due to the human morbidity and mortality it causes. Recombinant antigen for de non-structural protein NS1 from DEN4.
- West Nile virus: RNA virus of the family Flaviviridae which causes an emergent disease named West Nile Fever. The virus is transmitted through mosquito vectors, which bite and infect birds and also equines and humans. It may cause inflammation of the brain (encephalitis) or inflammation of the tissue that surrounds the brain and spinal cord (meningitis) Recombinant antigen EWNV.
- Skin and Buccal Membranes Diseases
- Other viral infectious:
- CMV Infection: is a herpes viral genus of the Herpesviruses group: in humans it is commonly known as HCMV or Human Herpesvirus 5 (HHV-5). CMV belongs to the betaherpesviridae family. All herpesviruses share a characteristic ability to remain latent within the body over long periods of time. HCMV infection is more widespread in developing countries and in communities with lower socioeconomic status and represents the most significant viral cause of birth defects in industrialized countries. Recombinant antigens: pp65, pp72, pp52.
- Epstein-Barr virus (EBV): is a member of the herpesvirus family and
one of the most common human viruses. The virus occurs
worldwide, and most people become infected with EBV sometime
during their lives. Infants become susceptible to EBV as soon as
maternal antibody protection disappears. When infection with EBV
occurs during adolescence or young adulthood, it causes infectious
mononucleosis 35% to 50% of the time. In humans, EBV is also
associated with cancer, although it is a late event in a very few carriers of this virus,
in particular Burkitt’s lymphoma, nasopharyngeal carcinoma, Hodgkin’s disease, and immunoblastic
lymphoma. Recombinant antigens: p138, p54, EBNA.
- Enteroviruses: Enteroviruses affect millions of people worldwide each year, and are often found in the respiratory secretions (e.g., saliva, sputum, or nasal mucus) and stool of an infected person. There are 62 non-polio enteroviruses that can cause disease in humans:23 Coxsackie A viruses, 6 Coxsackie B viruses, 28 echoviruses, and 5 other enteroviruses Infection can result in a wide variety of symptoms ranging from mild respiratory illness, acute and severe. They are positive-sense single-stranded RNA viruses associated with several human and mammalian diseases.
- Coxsackieviruses are part of the enterovirus family of viruses that live in the human digestive tract. They can spread from person to person, usually on unwashed hands and surfaces contaminated by feces, where they can live for several days. In most cases, coxsackieviruses cause mild flu-like symptoms and go away without treatment. But in some cases, they can lead to more serious infections. Recombinant antigen VP1.
- Candidiasis: is caused by infection with species of the genusCandida, predominantly with Candida albicans. Candida species are ubiquitous fungi that represent the most common fungal pathogens that affect humans. Candida species produce a wide spectrum of diseases, ranging from superficial mucocutaneous disease to invasive illnesses, such as hepatosplenic candidiasis, Candida peritonitis, and systemic candidiasis, when candida albicans enters the bloodstream and causes serious infection of vital organs. This is produced in rare instances, when body resistance is low as in leukemia or AIDS. Recombinant antigen enolase.
- Diseases produced by protozoa:
- Leishmaniosis: disease caused by protozoan parasites that belong to the genus Leishmania and the Trypanosomatidae family. This disease, due to its zoonotic nature can affect to humans and dogs, being transmitted by wild animals as asymptomatic reservoirs. This parasite is transmitted by the bite of certain species of sand fly, Phlebotomus and Lutzomya. Leishmaniosis causes different clinical manifestations ranging from self-healing cutaneous lesions (CL), mucosal lesions (MCL) to fatal visceral infections (VL) Recombinant antigens: K39, KMP11.
- The Chagas disease: is a tropical parasitic disease caused by the flagellate protozoan Trypanosoma cruzi. This protozoa is commonly transmitted to humans and other mammals by an insect vector, the blood-sucking of the subfamily Triatominae (Triatoma, Rhodnius, and Panstrongylus genera). The disease may also be spread through blood transfusion and organ transplantation, ingestion of food contaminated with parasites, and from a mother to her fetus. Recombinant antigens: 1F8, FRA.
- Toxoplasma: is a worldwide endemic disease caused by Toxoplasma gondii infecting a broad spectrum of vertebrate hosts, including humans. Toxoplasma gondii infection can cause
toxoplasmic encephalitis in immunocompromised patients, blindness, abortion, fetal abnormalities or even prenatal death in congenital cases. Recombinant antigen p30.
- Diseases produced by the HIV (human immunodeficiency virus):
- The disease of the human immune system caused by the human immunodeficiency virus (HIV) is the acquired immunodeficiency syndrome (AIDS). The illness interferes with the immune system making people with AIDS much more likely to get infections, including opportunistic infections that do not affect people with working immune systems. Recombinant antigen p24.