Rekom Biotech is a biotechnology company focused on the design and production of validated biomarkers for human and animal infectious diseases. Its products aimed at the in vitro diagnostic industry are versatile recombinant antigens which can be used as high quality raw material for the production of diagnostic tests by using different platforms, among others: second and third generation ELISAs, immunochromatography, chemiluminescence, Western blot, dot-blot, etc.
Our biomarkers are recombinant antigens produced in different expression systems. Our main aim is the optimisation of the antigenicity and the reduction of potential specificity problems. In order to reach this goal, we validate the antigen immunoreactivity towards specimen sera.
Rekom Biotech also offers R&D support services for IVD manufacturers that want to develop a new assay and cannot find the right raw material. We develop gene amplification and expression services, optimisation-expression studies, culture scale-up in bioreactors by using a fed-batch mode, process development strategies, downstream processing and immunologic studies by using Western Blot and ELISA assays.
MISSION
In Rekom Biotech our mission is to offer high quality recombinant antigens to be used as biomarkers for IVD diagnostic of human and animal infectious diseases.
Our working philosophy gives priority to the establishment of alliances and collaborations which will allow us to set up new prototypes and develop new products.
VISION
Rekom Biotech wants to become a reference supplier of biomarkers for human and animal infectious diseases in the IVD industry.
We like to work closely with IVD manufacturers to understand their problems and provide them with products totally adapted to their needs. In Rekom Biotech, we support our customers through the development process to overcome the challenges of applying the biomarkers to a specific platform.
We want to mantain our competitiveness through constant innovation in our products. In order to achieve this goal, we encourage continued training and creativity in our team. We give capital importance to participation and collaboration in scientific projects.
100% multidisciplinary team
Our team is formed by professional people who come from different knowledge areas: Molecular Biologist PhDs, Chemical Engineer PhDs, Computer Science PhD, chemists, senior laboratory technicians and our sales team. We are deeply involved in the development and the progress of the company and therefore we are in on-going formation.
ANA CAMACHO | CEO and cofounder Doctor in Molecular Biology
She has an experience of more than 26 years in design and development of processes regarding the obtaining of recombinant proteins related to infectious diseases. She completed her PhD in the Institute of Parasitology and Biomedicine “López-Neyra” (Granada) and subsequently she worked as a postdoctoral researcher in the Spanish National Biotechnology Centre (Madrid).
After this period, she set up the Molecular Biology department of the biotechnology company Vircell, S,L, working there for eight years heading the Molecular Biology-1 department, focused on the design and development of recombinant antigens related to infectious diseases.
In 2010 she established the biotechnology company Rekom Biotech in collaboration with the doctors Fernando Camacho Rubio and José Camacho Páez.
FERNANDO CAMACHO | Cofounder Full Professor in Chemical Enginieering, UGR
He has participated in 214 publications, he has supervised 39 Doctoral Thesis and he has worked in several Spanish Universities: Complutense University (Madrid), La Laguna University (Tenerife) and Granada University. He specialises in bio-process kinetics and bioreactor operations, not only with in vitro enzymes but also with aerobic and photosynthetic microorganisms.
From 1978 to 2001 he was the director of the research group of “Bioreactors” for the Andalusian Government. His experiences has allowed him the optimization of the conditions for working with commercial bioreactors in order to obtain microorganisms for a specific aim. It is notorious his experience in advising companies belonging to the chemistry and biotechnology sector. Co-founder of the company Rekom Biotech as collaborator in the University of Granada.
JOSÉ CAMACHO | Cofounder Doctor at the Department of Signal Theory, Telematics and Communications, UGR
He holds a Ph.D. in Computer Science from the Technical University of Valencia (2007) and has worked as a post-doctoral fellow in the University of Girona.
His research interest is focused on exploratory data analysis, monitoring, control and optimization with multivariate data analysis techniques applied to data of very different nature, including industrial processes, medicine and networking.
In Rekom Biotech we have a social responsibility with our team. This responsibility is reflected in flexible working hours and the balance between professional and personal life. We promote continued formation of our team and adopt different measures to maintain motivation and our company objectives.
Our concenr for the enviroment has led us to chose an environmentally friendly way of working, also within our team, including the installation of the latest extraction and filtering systems and our protocols for collection of toxic waste.
Ana Camacho scientific experience
Enrique Villegas, José Gutiérrez, Luis G. Giménez, José Rojas, Antonio Sorlózano, Almudena Rojas, Joaquín Mendoza and Ana G. Camacho. Chapter Searching immunogens by screening an expression library for the development of a Chlamydia pneumoniae diagnostic kit, in book Advances in Medicine and Biology, Volume 37. 2011. Publisher: Nova Biomedical Books. New York, USA., Editors: Berhardt LV, pp.87-104.
Mercedes Pérez-Ruiz, Jose-María Navarro-Mari, Maria-Fé Bautista-Marín, Irene Pedrosa-Corral, Sara Sanbonmatsu-Gámez, Ana G. Camacho, José Rojas, Jorge Ruiz-Ortiz, Javier Rodríguez-Granger and José Antonio Carrillo. Preliminary evaluation of a rapid oligochromatographic assay for the specific detection of new human inflluenza A H1N1 virus. 2010. Journal of Clinical Microbiol. 48 (5):1801-1805.
L.G. Giménez, Rojas, J., Rojas, A., Mendoza, J. and Camacho AG. SARS-associated coronavirus diagnostic kit: development of an ELISA-based antibody detection test with a cocktail of nucleocapsid and spike SARS-CoV proteins 2009. Clinical and vaccine Immunology. Vol 16, Nº 2: 241-245.
E. villegas, Camacho AG., Carrillo, JA, Sorlozano, A, Rojas, J., and Gutierrez, J. Emerging strategies in the diagnosis, prevention and treatment of Chlamydophila pneumoniae infections. Expert Opinión on Therapeutic Patents. 2008 , Vol 18, Nº. 10: 1175-1189.
E. villegas, Sorlozano, A, Camacho AG. and Gutierrez, J. Chlamydophila pneumoniae: desde su proteómica hasta la arteriosis. Enfermedades Infecciosas y Microbiología Clínica. 2007. Vol 26, Nº 10.
Ana Laín, Maria D. Morales, Juan Carlos Garcísa Ruiz, Joaquín Mendoza, Ana Camacho, Amalia de Palacio, José Pontón. Evaluation of a novel enzyme-linked immunosorbent assay to detect immunoglobulin G antibody to enolase for serodiagnosis of invasive candidiasis. Clin Vaccine Immunol. 2007,14:318-319.
JM Peula-García, J. Rojas, Camacho AG, JA Molina-Bolivar, J. Aguiar, C. Carnero-Ruiz. Use of n-octyl-E-D-thioglucopyranoside in the isolation of a bacterial membrane protein: an improved method for immunological applications. Journal of Surface Science and Technology, 2006, Vol. 22, No 3-4:141-157.
Virginia S. Lioy, M. Teresa Martín, Ana G. Camacho, Rudi Lurz, Haike Antelmann, Michale Hecker, Ed Hitchin, Yvonne Ridge, Jerry M. Wells, and J. C. Alonso. pSM19035-encoded zeta toxin induces stasis followed by death in a subpopulation of cells. Microbiology 2006:152:2365-79.
Gutierrez, J., Linares, J., Camacho A.G, Palanca, M., Maroto, C., Ros, E., Luna JD, José Soto M, Sorlozano, A. Description of immunogens of Chlamydophila pneumoniae recognized by serum of individuals with peripheral artery disease. Med. Clin. 2006 May 20; 126 (19):721-7.
Camacho AG, Gual A, Lurz R, Tavares P, Alonso JC. Bacillus subtilis bacteriophage SPP1 DNA packaging motor requires terminase and portal proteins. 2003. J Biol Chem., 278: 23251-23259.
Camacho AG, Misselwitz R, Behlke J, Ayora S, Welfle K, Meinhart A, Lara B, Saenger W, Welfle H, Alonso JC. In vitro and in vivo stability of the z22 protein complex of the broad host-range Streptococcus pyogenes pSM19035 addiction system. 2002. Biol Chem., 383: 1713-1713.
Bernier-Villamor V, Camacho A.G., Hidalgo-Zarco F, Perez J, Ruiz-Perez LM, Gonzalez-Pacanowska D. Characterizationof desoxyuridine 5´-triphosphate nucleotidohydrolase from Trypanosoma cruzi. FEBS Lett. 2002, 526: 147-150.
Meinhart, A., Alings, C., Sträter, N., Camacho, A.G., Alonso, J.C. and Saenger, W. Crystallization and preliminary X-ray diffraction studies of the ez addiction system encoded by Streptococcus pyogenes plasmid pSM19035. Acta Crystallographica Section D. D57: 745-747.
Hidalgo-Zarco F, Camacho AG, Bernier-Villamor, V., Nord J., Ruiz-Pérez LM, Gonzalez-Pacanowska D. Kinetic properties and inhibition of the dimeric dUTPase-dUDPase from Leishmania major. 2001. Protein Science., 10: 1426-1433.
Gual A, Camacho AG, Alonso JC. Functional analysis of the terminase large subunit, G2P, of Bacillus subtilis bacteriophage SPP1. 2000. J Biol Chem., 275: 35311-35319.
Camacho AG, Hidalgo-Zarco F, Bernier-Villamor V, Ruiz-Perez LM, Gonzalez-Pacanowska D. Properties of Leishmania major dUTP nucleotidohydrolase, a distinct nucleotide-hydrolysing enzyme in kinetoplastids. 2000. Biochem J., 346: 163-168.
Bernier-Villamor, V., Camacho A.G., Gonzalez-Pacanowska D, Cedergren-Zeppezauer E, Antson, A., Wilson, KS. Crystallization and preliminary X-ray diffraction of Trypanosoma cruzi dUTPase. 1999. Acta Crystallogr D Biol Crystallogr., 55: 528-530.
Perez J, Gallego C, Bernier-Villamor V, Camacho A.G., Gonzalez-Pacanowska D, Ruiz-Perez LM. Apurinic/apyrimidinic endonuclease genes from the trypanosomatidae leishmania major and Trypanosoma cruzi confer resistance to oxidizing agents in DNA repair-deficient Escherichia coli. 1999. Nucleic Acids Res., 27: 771-777.
Dolores Gonzalez-Pacanowska D., Ana G. camacho Páez, Javier Peña Díaz, Claribel Gallego García, Esther Fárez Vidal, Ramón Hurtado Guerrero, Victor Bernier Villamor, Andrea Montalbetti y Luis Miguel Ruiz Pérez. Blancos de acción de fármacos en protozoos parásitos: caracterización molecular y desarrollo de estrategias para el diseño de inhibidores específicos. Jornadas sobre investigación en Medicina 350-362 (1998). Unidad Mixta de investigaciones médicas. I.S.B.N.: 84-8497-303-4, GR/189-1998.
Camacho AG, Arrebola, R., Peña-Díaz, J., Ruiz-Perez LM., Gonzalez-Pacanowska D. Description of a novel eukariotic desoxyuridine 5´-triphosphate nucleotidohydrolase in Leishmania major. 1997. Biochem J., 325: 441-7.
Peña-Díaz, J, Montalvetti, A., Camacho AG, Gallego C., Ruiz-Perez LM., Gonzalez-Pacanowska D. A soluble 3-hydroxy-3-methylglutaryl-CoA reductase in the protozoan Trypanosoma cruzi. 1997. Biochem J., 324: 619-626.
Arrebola R., Olmo, A., Camacho AG, Ruiz-Perez LM., Gonzalez-Pacanowska D. A mutant dihydropholate reductase-thymidylate synthase from Leishmania major as a selectable marker in transfection experiments. 1996. Mol. Biochem. Parasitol., 79: 129-133.
Fernando Camacho scientific experience
Garcia-Camacho, F.; Sanchez-Miron, A.; Molina-Grima, E.; Camacho Rubio, F.; Merchuck, J. A mechanistic model of photosynthesis in microalgae including photoacclimation dynamics. 2012. Journal of Theoretical Biology., 304, 1−15.
Pacheco, R; Sánchez, A; La Rubia, MD; López, AB; Sánchez, S, Camacho Rubio, F.. Thermal Effects in the Absorption of Pure CO2 into Aqueous Solutions of 2-Methyl-amino-ethanol, 2012. INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH, 51: 4809-4818.
González-Tello, P.; Camacho Rubio, F.; Vicaria JM y González, PA. Analysis of the Mean Diameters and Particle-Size Distribution in Powders, 2012, PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION, 27: 158-164.
Camacho Rubio, F.; Jurado, E; Luzón, G; Vicaria, JM. Development and analysis of an integral fluidodynamic model in hollow fibre for different operational modes. 2010. JOURNAL OF MEMBRANE SCIENCE, 347: 116-131
Jurado, E; Fernandez-Serrano, M; Camacho Rubio, F; Núñez Olea, J; Lechuga, M; Luzón, G. Development and application of kinetic models for the primary biodegradation of non-ionic surfactants. 2009. CHEMICAL ENGINEERING JOURNAL, 150: 440-446
González-Tello,P; Camacho Rubio, F; Guadix, EM; Luzón, G; González, PA. Density, viscosity and surface tension of whey protein concentrate solutions. 2009. JOURNAL OF FOOD PROCESS ENGINEERING, 32(2): 235-247
Jurado, E; Camacho Rubio, F; Luzón, G; Fernandez-Serrano M; García-Román M Kinetic of the enzymatic hydrolysis of triglycerides in o/w emulsions. Study of the initial rates and the reaction time course. 2008. BIOCHEMICAL ENGINEERING JOURNAL, 40: 473-484
de la Casa EJ; Guadix, A; Ibáñez R.; Camacho Rubio, F; Guadix, EM. A combined fouling model to describe the influence of the electrostatic environment on the cross-flow microfiltration of BSA. 2008. JOURNAL OF MEMBRANE SCIENCE, 318 (1-2): 247-254
Camacho Rubio, F; Robles, A; Camacho, B; González PA; Esteban L; Molina E. Modeling of the kinetic for the acidolysis of different triacylglycerols and caprylic acid catalyzed by Lipozyme IM immobilized in packed bed reactor. 2007. CHEMICAL ENGINEERING SCIENCE, 62 (12): 3127-3141
Jurado, E; Bravo, V; Camacho Rubio, F; Vicaria JM; Fernandez-Arteaga A. Estimation of the distribution of droplet size, interfacial area and volume in emulsions. 2007. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 295 (1-3): 91-98
Jurado, E; Camacho Rubio, F; Luzón, G; Vicaria JM. Influence of the hollow-fibre membrane on the stability of beta-galactosidase and on lactose hydrolysis - Kinetic models including adsorption of the enzyme onto the membrane. 2006. ENZYME AND MICROBIAL TECHNOLOGY, 39 (5): 1008-1015
Jurado, E; Camacho Rubio, F; Luzón, G; Fernandez-Serrano M; García-Román M. Kinetic model for the enzymatic hydrolysis of tributyrin in O/W emulsions. 2006. CHEMICAL ENGINEERING SCIENCE, 61 (15): 5010-5020
Camacho Rubio, F; Robles, A; González, PA; Camacho B; Esteban L; Molina E. Mechanistic model for the lipase-catalyzed alcoholysis of triacylglycerols. 2006. APPLIED CATALYSIS A-GENERAL, 301 (2): 158-168
Guadix, A; Camacho Rubio, F; Guadix, EM. Production of whey protein hydrolysates with reduced allergenicity in a stable membrane reactor. 2006 JOURNAL OF FOOD ENGINEERING, 72 (4): 398-405
Camacho Rubio, F; Jurado, E; Luzón, G; Fernandez-Serrano M; García-Román M. Enzymatic hydrolysis of tributyrin in O/W emulsions. 2005. AFINIDAD, 62 (520): 597-604
Jurado, E; Camacho Rubio, F; Luzón, G; Vicaria JM. Kinetic and enzymatic adsorption model in a recirculation hollow-fibre bioreactor. 2005. BIOPROCESS AND BIOSYSTEMS ENGINEERING, 28 (1): 27-36
Camacho Rubio, F; Sanchez, S; Pacheco, R; La Rubia MD. Thermal effects of CO2 absorption in aqueous solutions of 2-amino-2-methyl-1-propanol. 2005. AICHE JOURNAL, 51 (10): 2769-2777
Moreno, PAG; Medina, AR; Camacho Rubio, F; Camacho B; Esteban L; Molina E. Production of structured triacylglycerols in an immobilised lipase packed-bed reactor: batch mode operation. 2005. JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY, 80 (1): 35-43
Camacho Rubio, F; Mirón, AS; Garcia, MCC; Camacho FG; Grima EM; Chisti Y. Mixing in bubble columns: a new approach for characterizing dispersion coefficients. 2004. CHEMICAL ENGINEERING SCIENCE, 59 (20): 4369-4376
Moreno, PAG; Medina, AR; Camacho Rubio, F; Paez BC; Grima EM. Production of structured lipids by acidolysis of an EPA-enriched fish oil and caprylic acid in a packed bed reactor: Analysis of three different operation modes. 2004. BIOTECHNOLOGY PROGRESS, 20 (4): 1044-1052
Sánchez, S; Bravo, V; Moya, AJ; Castro E; Camacho Rubio, F. Influence of temperature on the fermentation of D-xylose by Pachysolen tannophilus to produce ethanol and xylitol. 2004. PROCESS BIOCHEMISTRY, 39 (6): 673-679
Jurado, E; Camacho Rubio, F; Luzón, G; Vicaria JM. Kinetic model for lactose hidrolysis in a recirculation hollow-fibre bioreactor. 2004. CHEMICAL ENGINEERING SCIENCE, 59 (2): 397-405
Jurado, E; Camacho Rubio, F; Luzón, G; Vicaria JM. Kinetic models of activity for beta-galactosidases: influence of pH, ionic concentration and temperature. 2004. ENZYME AND MICROBIAL TECHNOLOGY, 34 (1): 33-40
Paez, BC; Medina, AR; Camacho Rubio, F; Moreno PG; Grima EM. Modeling the effect of free water on enzyme activity in immobilized lipase-catalyzed reactions in organic solvents. 2003. ENZYME AND MICROBIAL TECHNOLOGY, 33 (6): 845-853
Paez, BC; Medina, AR; Camacho Rubio, F; Cerdan LE; Grima EM. Kinetics of lipase-catalysed interesterification of triolein and caprylic acid to produce structured lipids. 2003. JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY, 78 (4): 461-470 APR 2003
Camacho Rubio, F; Camacho, FG; Sevilla, JMF; Chisti Y; Grima EM. 2003. A mechanistic model of photosynthesis in microalgae. BIOTECHNOLOGY AND BIOENGINEERING, 81 (4): 459-473
Jurado, E; Camacho Rubio, F; Luzón, G; Vicaria JM. A new kinetic model proposed for enzymatic hydrolysis of lactose by a beta-galactosidase from Kluyveromyces fragilis. 2002. ENZYME AND MICROBIAL TECHNOLOGY, 31 (3): 300-309
Paez, BC; Medina, AR; Camacho Rubio, F; Moreno PG; Grima EM. Production of structured triglycerides rich in n-3 polyunsaturated fatty acids by the acidolysis of cod liver oil and caprylic acid in a packed-bed reactor: equilibrium and kinetics. 2002. CHEMICAL ENGINEERING SCIENCE, 57 (8): 1237-1249
Sánchez, S; Bravo, V; Castro, E; Moya AJ; Camacho Rubio, F. The fermentation of mixtures Of D-glucose and D-xylose by Candida shehatae, Pichia stipitis or Pachysolen tannophilus to produce ethanol. 2002. JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY, 77 (6): 641-648
Hoyos, SEG; Nieto, LM; Camacho Rubio, F; Cormenzana AR. Kinetics of aerobic treatment of olive-mill wastewater (OMW) with Aspergillus terreus. 2002. PROCESS BIOCHEMISTRY, 37 (10): 1169-1176
Camacho Rubio, F; Garcia, JL; Molina, E; Chisti Y. Axial inhomogeneities in steady-state dissolved oxygen in airlift bioreactors: predictive models. 2001. CHEMICAL ENGINEERING JOURNAL, 84 (1): 43-55
Blázquez, G; Camacho Rubio, F; Calero, M; Alarcón FJ. Interaction probabilities in a four components aqueous two-phase system: polymer plus salt plus water plus protein. 2001. CHEMICAL ENGINEERING SCIENCE, 56 (14): 4451-4456
Camacho Rubio, F; González-Tello, P; Paez-Dueñas, MP; Guadix EM; Guadix A. Correlation of base consumption with the degree of hydrolysis in enzymic protein hydrolysis. 2001. JOURNAL OF DAIRY RESEARCH, 68 (2): 251-265
Molina, EM; Fernandez, FG; Camacho, FG; Camacho Rubio, F; Chisti Y. Scale-up of tubular photobioreactors. 2000. JOURNAL OF APPLIED PHYCOLOGY, 12 (3-5): 355-368
Jurado, E; Camacho Rubio, F; Luzón, G; Vicaria JM. Recirculation hollow-fiber bioreactor for enzymatic reactions: kinetic model for fructose-glucose isomerisation. 2000. AFINIDAD, 57 (488): 283-288
Sobczuk, TM; Camacho, FG; Camacho Rubio, F; Fernandez FGA; Grima EM. Carbon dioxide uptake efficiency by outdoor microalgal cultures in tubular airlift photobioreactors. 2000. BIOTECHNOLOGY AND BIOENGINEERING, 67 (4): 465-475 FEB 20 2000
Sánchez, S; Bravo, V; Castro, E; Moya AJ; Camacho Rubio, F. Comparative study of the fermentation of D-glucose/D-xylose mixtures with Pachysolen tannophilus and Candida shehatae. 1999. BIOPROCESS ENGINEERING, 21 (6): 525-532
Camacho Rubio, F; Garcia, JL; Molina, E; Chisti Y. Steady-state axial profiles of dissolved oxygen in tall bubble column bioreactors. 1999. CHEMICAL ENGINEERING SCIENCE, 54 (11): 1711-1723
Camacho Rubio, F; Fernandez, FGA; Perez, JAS; Camacho FG; Grima E. Prediction of dissolved oxygen and carbon dioxide concentration profiles in tubular photobioreactors for microalgal culture. 1999. BIOTECHNOLOGY AND BIOENGINEERING, 62 (1): 71-86
Guadix A; Guadix EM; Páez MP; González Tello P; Camacho Rubio, F.Procesos Tecnológicos y métodos de control en la hidrólisis de proteínas. 1999. Ars Pharmaceutica, 41:1, 79-89
González Tello P; Guadix EM; Camacho Rubio, F; Garach A. Mathematical modelling and computer simulation in spray drying of whey protein hydrolysates. 1999. AIDIC Conference Series, 4, 71-76
Sánchez, S; Bravo, V; Castro, E; Moya AJ; Camacho Rubio, F. The production of xylitol from D-xylose by fermentation with Hansenula polymorpha. 1998. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 50 (5): 608-611
Camacho Rubio, F; Gonzalez-Tello, P; Guadix, EM. Influence of enzymes, pH and temperature on the kinetics of whey protein hydrolysis. 1998. FOOD SCIENCE AND TECHNOLOGY INTERNATIONAL, 4 (2): 79-84
Blázquez, G; Camacho Rubio, F; González-Tello, P; Alarcón FJ. Partition coefficients of alpha-amylase in aqueous two-phase systems PEG+MgSO4 center dot 7H(2)O+H2O at 298K. 1998. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 1379 (2): 191-197
Sánchez, S; Bravo, V; Castro, E; Moya AJ; Camacho Rubio, F. The influence of pH and aeration rate on the fermentation of D-xylose by Candida shehatae. 1997. ENZYME AND MICROBIAL TECHNOLOGY, 21 (5): 355-360
Camacho Rubio, F; Paez, MP; Jimenez, MC; Fernandez M. Application of the sodium dithionite oxidation to measure oxygen transfer parameters. 1997. CHEMICAL ENGINEERING SCIENCE, 52 (8): 1387-1391
Camacho Rubio, F; González Tello P; Guadix EM; Pardo F. Hidrolizados enzimaticos de proteínas para nutrición enteral: cinética de la hidrólisis. 1997. Acta A, VII, 31-37
Martinez, ME; Camacho Rubio, F; Jimenez, JM; Espinola JB. Influence of light intensity on the kinetic and yield parameters of Chlorella pyrenoidosa mixotrophic growth. 1997. PROCESS BIOCHEMISTRY, 32 (2): 93-98
Camacho Rubio, F; Nieto, LM; Serrano, MF; Jimenez MC. Batch culture of Azotobacter vinelandii under oxygen limitation conditions. 1996. ANALES DE QUIMICA, 92 (5): 288-293
González Tello, P; Camacho Rubio, F; Jurado, E; Guadix EM. A simple method for obtaining kinetic equations to describe the enzymatic hydrolysis of biopolymers. 1996. JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY, 67 (3): 286-290
Camacho Rubio, F; Jurado E; González Tello P; Luzón G. A comparative study of the activity of free and immobilized enzymes and its application to glucose isomerise. 1996.CHEMICAL ENGINEERING SCIENCE, 51, 4159-4165
Camacho Rubio, F; Jurado E; González Tello P; Luzón G. Kinetic Study of Fructose-Glucose Isomerization in a Recirculation Reactor. 1995. THE CANADIAN J. OF CHEM. ENG., 73 , 935-940
Camacho Rubio, F; Blázquez G; Jimenez MC; Fernandez M. Determinación de parámetros de transferencia de oxígeno en fermentadores. 1995. Revista de la Real Academia de Ciencias Exactas, Físicas y Naturales de Madrid, LXXXIX, 235-243
Bravo, V; Camacho Rubio, F; Sánchez, S; Castro E. Influence of the concentrations of d-xylose and yeast extract on ethanol-production by Pachysolen-tannophilus. 1995. JOURNAL OF FERMENTATION AND BIOENGINEERING, 79 (6): 566-571
Camacho Rubio, F; Páez, MP; Blázquez, G; Jimenez MC; Fernández M. Influence of pH on the oxygen absorption kinetics in alkaline sodium dithionite Solutions. 1995. CHEMICAL ENGINEERING SCIENCE, 50 (7): 1181-1186
Camacho Rubio, F; Alameda, EJ; Tello, PG; Luzón G. Fructose-glucose enzymatic isomerization. 1994. ANALES DE QUIMICA, 90 (2): 195-200
Camacho Rubio, F; Alameda, EJ; Tello, PG; Luzón G. The effectiveness factor for immobilized enzymes. 1994. ANALES DE QUIMICA, 90 (3-4): 278-283 1994
Nieto, LM; Camacho Rubio, F; Vives, SR; Calatrava F. Continuous anaerobic etanolic fermentation with a strain of Saccharomyces-cerevisiae alcohol resistant. 1993. ANALES DE QUIMICA, 89 (5-6): 579-583
González Tello P; Camacho Rubio F; Jurado E; Sánchez R. Kinetics of the hydrolysis of soluble starch by glucoamylase.- 1993. INT. CHEM. ENG., 33, 450-455
Bravo, V; Camacho Rubio, F; Sánchez, S; Castro E. The effect of pH on kinetic and yield parameters during the ethanolic fermentation of D-xylose with Pachysolen-tannophilus. 1993. BIOPROCESS ENGINEERING, 9 (4): 159-165
Camacho Rubio, F; Tello, PG; Dueñas, MP; Moreno, MCM; Cuadrado V. Hydrolysis of casein by alcalase. 1993. REVISTA ESPANOLA DE CIENCIA Y TECNOLOGIA DE ALIMENTOS, 33 (1): 59-70
Nieto, LM; Hoyos, SEG; Camacho Rubio, F; García P; Ramos A. The biological purification of waste products from olive oil extraction. 1993. BIORESOURCE TECHNOLOGY, 43 (3): 215-219
Camacho Rubio F; González P; Márquez M; Guadix EM. Hidrolizados enzimáticos de interés en la I.A.A. II. Hidrolizados enzimáticos de proteínas. 1992. ALIMENTACIÓN, EQUIPOS Y TECNOLOGÍA, 174-180
Camacho Rubio, F; Dueñas, PP; García, GB. Glucose-oxidation kinetic-study in the presence of glucose-oxidase using a steady-state method. 1992. ANALES DE QUIMICA, 88 (7-8): 650-656
Camacho Rubio, F; Tello, PG; Alameda, EJ; Guadix EM. Enzymatic-hydrolysis of whey proteins. 1992. ANALES DE QUIMICA, 88 (5-6): 568-572
Camacho Rubio, F; Dueñas, MPP; García, GB; Garrido JM. Oxygen absorption in alkaline sodium dithionite solutions. 1992. CHEMICAL ENGINEERING SCIENCE, 47 (17-18): 4309-4314
González Tello, P; Camacho Rubio, F; Jurado, E; Bailón R. Influence of surfactant concentration on the final rising rate of droplets. 1992. CANADIAN JOURNAL OF CHEMICAL ENGINEERING, 70 (3): 426-430
Tello, PG; Camacho Rubio, F; Alameda, EJ; Robles A; Palacios R. Hydrolysis of cellulose with cellulases and beta-1,4-glucosidase. 1991. AFINIDAD, 48 (432): 91-95
Rodriguez, VB; Camacho Rubio, F; Dueñas, MPP; Reyes A. Activity tests of beta-1,4-glucosidase in T-reesei cellulases considering enzyme deactivation. 1991. AFINIDAD, 48 (432): 110-114
Camacho Rubio, F; Molina, E; Valdes, F; Andujar JM. Influence of operating and physical variables on interfacial area determination. 1991. AICHE JOURNAL, 37 (8): 1196-1204
Rodriguez, VB; Camacho Rubio, F; Sancho, MEM; Sanchez P. Lineal growth in the ethanolic fermentation of xylose with Pachysolen-tannophilus. 1990. AFINIDAD, 47 (429): 329-335
Tello, PG; Camacho Rubio, F; Alameda, EJ; Sanchez R. A kinetic expression for hydrolysis of soluble starch by glucoamylase. 1990. ANALES DE QUIMICA, 86 (7): 728-732
Rodriguez, VB; Camacho Rubio, F; Dueñas, MPP; Reyes A. Loss of beta-1,4-glucosidase activity in the cellulases from t-reesei. 1990. ANALES DE QUIMICA, 86 (2): 208-212
Tello, PG; Camacho Rubio, F; Medina, AR; Morales LJ. Enzymatic-hydrolysis of wheat-flour using alpha-amylase from A-oryzae. 1990. REVISTA DE AGROQUIMICA Y TECNOLOGIA DE ALIMENTOS, 30 (1): 51-58
Camacho Rubio F; Molina E; Martínez ME; Sánchez S; García F. Continuous culture of the microalgae Tetraselmis sp. Productivity Analysis. 1990. AQUACULTURE, 90, 75-84
Grima, EM; Camacho Rubio, F; Sanz, FV; Capel LL. Determination of interfacial-areas in stirred tanks - influence of the tank geometry and sparger arrangement. 1990. AFINIDAD, 47 (425): 13-18
Bravo V; Camacho Rubio F; Sánchez S; Castro E. The influence of the initial concentrations of glucose and yeast extract on the ethanolic ferm. by P. tannophilus. 1990. COLLECT. CZECH. CHEM. COMMUN., 55, 854-866
Camacho Rubio F; Martínez ME; Sánchez S. Contenido en clorofila en C. pyrenoidosa durante el crecimiento heterotrófico sobre monosacáridos. 1989. AFINIDAD, 46, 151-153
González Tello P; Camacho Rubio F; Robles Medina A. Hidrolizados enzimáticos de interés en la I.A.A. I. Hidrolizados de cereales. 1989. ALIMENTACIÓN, EQUIPOS Y TECNOLOGÍA, 201-207
Tello, PG; Camacho Rubio, F; Medina, AR; Moreno MJ. Enzymatic-hydrolysis of wheat straw treated with diluted H2SO4. 1989. AFINIDAD, 46 (424): 502-506
Camacho Rubio, F; Sancho, MEM; Villasclaras, SS; Perez AD. Influence of pH on the kinetic and yield parameters of Scenedesmus-obliquus heterotrophic growth. 1989. PROCESS BIOCHEMISTRY, 24 (4): 133-136
Camacho Rubio, F; Sancho, MEM; Villasclaras, SS. Monosaccharides consumption by Chlorella-pyrenoidosa. 1989. ANALES DE QUIMICA SERIE A-QUIMICA FISICA Y QUIMICA TECNICA, 85 (2): 313-316
Camacho Rubio, F; Rodriguez, VB; Villasclaras, SS; Vico MC. The influence of temperature, pH and aeration on the ethanolic fermentation of glucose by Pachysolen-tannophilus. 1989. COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS, 54 (5): 1244-1256
Camacho Rubio, F; Grima, EM; Sanz, FV; Peral JMA. Determination of interfacial-areas in stirred sparged tanks - influence of tensioactives agents concentration. 1989. ANALES DE QUIMICA SERIE A-QUIMICA FISICA Y QUIMICA TECNICA, 85 (1): 118-122
Camacho Rubio, F; Tello, PG; Alameda, EJ; Medina AR. Influence of the NaOH/substrate relationship and the pre-treatment time on the enzymatic-hydrolysis of poplar wood. 1989. AFINIDAD, 46 (419): 36-40
Camacho Rubio, F; Dueñas, MPP; Martin, JMG. Oxygen absorption into sodium dithionite solutions .1. influence of dithionite concentration. 1988. ANALES DE QUIMICA SERIE A-QUIMICA FISICA Y QUIMICA TECNICA, 84 (3): 332-335
Camacho Rubio, F; Grima, EM; Sanz, FV; Canillas JA. Influence of pH, temperature and catalyst concentration on the oxidation of aqueous sodium-sulfite solution. 1988. ANALES DE QUIMICA SERIE A-QUIMICA FISICA Y QUIMICA TECNICA, 84 (3): 342-348
Camacho Rubio, F; Sancho, MEM; Villasclaras, SS. Influence of temperature on the heterotrophic growth of Chlorella-pyrenoidosa. 1988. ANALES DE QUIMICA SERIE A-QUIMICA FISICA Y QUIMICA TECNICA, 84 (3): 374-378
Nieto, LM; Camacho Rubio, F; Vives, SR; Romero MVM. Extraction and characterization of avocado oil. 1988. GRASAS Y ACEITES, 39 (4-5): 272-277
Camacho Rubio, F; Sancho, MEM; Villasclaras, SS. Influence of pH on the heterotrophic growth of Chlorella-pyrenoidosa. 1988. AFINIDAD, 45 (418): 497-502
Camacho Rubio, F; Rodriguez, VB; Dueñas, MPP. Influence of the denaturing of the enzyme in the enzymatic kinetics. 1988. AFINIDAD, 45 (418): 506-508
Camacho Rubio, F; Rodriguez, VB; Dueñas, MPP. Treatment of the data from enzymatic kinetics. 1988. AFINIDAD, 45 (417): 422-424
Camacho Rubio, F; Sancho, EM; Villasclaras, SS. Heterotrophic growth of Chlorella-pyrenoidosa on monosaccharides. 1988. ANALES DE QUIMICA SERIE A-QUIMICA FISICA Y QUIMICA TECNICA, 84 (3): 349-354
Camacho Rubio F; Martínez ME; Sánchez S. Aplicaciones de los cultivos de microalgas. 1988. INGENIERÍA QUÍMICA, 207-211
Camacho Rubio, F; Tello, PG; Alameda, EJ; Medina, AR. Influence of different chemical pretreatments on the enzymatic-hydrolysis of microcrystalline cellulose. 1988. ANALES DE QUIMICA SERIE A-QUIMICA FISICA Y QUIMICA TECNICA, 84 (2): 236-240
Camacho Rubio, F; Sancho, MEM; Villasclaras, SS; Perez, AD. Heterotrophic growth of Chlorella pyrenoidosa on carboxylic-acids. 1988. ANALES DE QUIMICA SERIE A-QUIMICA FISICA Y QUIMICA TECNICA, 84 (2): 241-245
Camacho Rubio, F; Nieto, LM; Vives, SR; Martin CS. Ethanolic fermentation with immobilized Saccharomyces cerevisiae. 1988. ANALES DE QUIMICA SERIE A-QUIMICA FISICA Y QUIMICA TECNICA, 84 (2): 246-250
Camacho Rubio, F; Sancho, MEM; Villasclaras, SS. Biomass and energetic yields of heterotrophic Chlorella pyrenoidosa growth in a batch culture. 1988. ANALES DE QUIMICA SERIE A-QUIMICA FISICA Y QUIMICA TECNICA, 84 (2): 251-255
Camacho Rubio, F; Grima, EM; Sanz, FV; Peral JMA. Determination of interfacial-areas in stirred sparged tanks - influence of operation variables. 1988. ANALES DE QUIMICA SERIE A-QUIMICA FISICA Y QUIMICA TECNICA, 84 (1): 99-105
Camacho Rubio F; Martínez Nieto L; Rodríguez Vives S. Fermentación etanólica con microorganismos inmovilizados. 1988. INGENIERÍA QUÍMICA, 129-135
Camacho Rubio, F; González Tello P; Jurado E; Robles A. Enzymatic hydrolysis of carboxymethyl cellulose. II. Model for two reactions in series with competitive inhibition by product. 1988. INT. CHEM. ENG., 28, 618-626
Camacho Rubio, F; Tello, PG; Dueñas, PP; García FJG. Influence of the surfactants on the rate of transference of oxygen in tanks of plane interface area. 1987. AFINIDAD, 44 (410): 344-346
Camacho Rubio, F; González, P; Jimenez, JM; Moya M. Influence of different NaOH pretreatments on the rate of enzymatic hydrolisis of wheat straw. 1987. REVISTA DE AGROQUIMICA Y TECNOLOGIA DE ALIMENTOS, 27 (2): 231-236
Camacho Rubio, F; Dueñas, MPP; Carretero, JM. Oxygen absorption by aqueous-solutions of Cu(I) - A chemical method for the determination of physical mass-transfer parameters. 1987. ANALES DE QUIMICA SERIE A-QUIMICA FISICA Y QUIMICA TECNICA, 83 (2): 195-199
Camacho Rubio, F; Dueñas, MPP; Carretero, JM. Kinetics of oxidation of Cu(I) by oxygen in aqueous-solutions. 1987. ANALES DE QUIMICA SERIE A-QUIMICA FISICA Y QUIMICA TECNICA, 83 (2): 200-205
Camacho Rubio, F; Rodríguez, VB; Dueñas, MPP; Cobo TM. Cellobiose hydrolysis with beta-1,4-glucosidase from almonds. 1987. ANALES DE QUIMICA SERIE A-QUIMICA FISICA Y QUIMICA TECNICA, 83 (1): 71-77
Camacho Rubio, F; Tello, PG; Alameda, EJ; Medina AR. Enzymatic hydrolisis of Cm-cellulose .1. Synergetic effect of endo and exo celluloses. 1987. ANALES DE QUIMICA SERIE A-QUIMICA FISICA Y QUIMICA TECNICA, 83 (1): 78-82
Camacho Rubio, F; Martínez Nieto L; Rodríguez Vives S. Fermentación alcohólica: estado actual y alternativas. 1987. INGENIERÍA QUÍMICA, 175-182
Camacho Rubio, F; Páez Dueñas MP; Blázquez García G. Tranferencia de materia con reacción química en líquidos. Aplicación a la cinética de orden n y a la cinética hiperbólica. 1986. ANALES DE QUÍMICA, 82, 584-589
Camacho Rubio, F; Dueñas PP. On the pre-steady state for 2 intermediates enzyme-kinetics. 1986. ANALES DE QUIMICA SERIE A-QUIMICA FISICA Y QUIMICA TECNICA, 82 (3): 534-541
Camacho Rubio, F; González P; Jurado E; Páez Dueñas MP. Aprovechamiento de residuos lignocelulósicos. Producción de etanol y SCP. Parte II. 1986. INGENIERÍA QUÍMICA, 117-123
Camacho Rubio, F; González P; JURADO E; Páez Dueñas MP. Aprovechamiento de residuos lignocelulósicos. Producción de etanol y SCP. parte I. 1985. INGENIERÍA QUÍMICA, 297-301
Camacho Rubio, F; Martínez Sancho ME. Development of a model for the effect of the intensity of light on the grow of Chlorella pyrenoidosa. 1985. INT. CHEM. ENG., 25, 289-294
Camacho Rubio, F; Padial Vico A; Martínez Sancho ME. The effect of the mean intensity of light on the cultivation of Chlorella pyrenoidosa. 1985. INT. CHEM. ENG., 25, 283-288
Camacho Rubio, F; Sancho, MEM. Influence of mean-light-intensity on the growth of Chlorella pyrenoidosa. 1983. ANALES DE QUIMICA SERIE A-QUIMICA FISICA Y QUIMICA TECNICA, 79, 265-270
Camacho Rubio, F; Sancho, MEM. A model to explain the effect of light-intensity on the growth of Chlorella pyrenoidosa. 1982. ANALES DE QUIMICA SERIE A-QUIMICA FISICA Y QUIMICA TECNICA, 78 (3): 376-380
Camacho Rubio, F; Hernández Armas, J; Limiñana de la Fe, G. Oxygen absorption by aqueous-solutions of sodium-sulfite. 1980. ANALES DE QUIMICA SERIE A-QUIMICA FISICA Y QUIMICA TECNICA, 76 (1): 106-113
José Camacho scientific experience
Camacho, J.Visualizing Big data with Compressed Score Plots: Approach and Research Challenges. Chemometrics and Intelligent Laboratory Systems, 2014, 135: 110-125.
Camacho, J., Ferrer, A.J. Cross-validation in PCA models with the element-wise k-fold (ekf) algorithm: Practical Aspects. Chemometrics and Intelligent Laboratory Systems, 2014, 131: 37-50.
Laurí, D., Lennox, B., Camacho, J.. Model predictive control for batch processes: Ensuring validity of predictions. Journal of Process Control, 2014, 24 (1): 239-249.
González-Martinez, J.M., Camacho, J., Ferrer, A.J. Bilinear Modelling of Batch Processes. Part III: Parameter Stability. Journal of Chemometrics, 2014, : -.
Camacho, J., Padilla, P., García-Teodoro, P., Díaz-Verdejo, J. A Generalizable Dynamic Flow Pairing Method for Traffic Classification. Computer Networks, 2013, 57 (14): 2718-2732.
Padilla, P., Camacho, J., Maciá-Fernández, G., Díaz-Verdejo, J., García-Teodoro, P., Gómez-Calero, C. On the Influence of the Propagation Channel in the Performance of Energy-Efficient Geographic Routing Algorithms for Wireless Sensor Networks (WSN). Wireless Personal Communications, 2013, 70 (1): 15-38.
Camacho, J., Ferrer, A.J. Cross-validation in PCA models with the element-wise k-fold (ekf) algorithm: theoretical aspects. Journal of Chemometrics, 2012, 26 (7): 361-373.
Camacho, J.Observation-based missing data methods for exploratory data analysis to unveil the connection between observations and variables in latent subspace models. Journal of Chemometrics, 2011, 25 (11): 592-600.
Camacho, J., Padilla, P., Díaz-Verdejo, J., Smith, K., Lovett, D. Least-squares approximation of a space distribution for a given covariance and latent sub-space. Chemometrics and Intelligent Laboratory Systems, 2011, 105 (2): 171-180.
Camacho, J. Missing-data theory in the context of Exploratory Data Analysis. Chemometrics and Intelligent Laboratory Systems, doi:10.1016/j.chemolab.2010.04.017.
Camacho, J., Picó, J., Ferrer, A.J. Data understanding with PCA: Structural and Variance Information plots. Chemometrics and Intelligent Laboratory Systems, 2010, 100(1): 48-56.
Camacho, J., Picó, J., Ferrer, A.J. On-line monitoring of batch processes based on PCA: Does the modelling structure matter? Analytica Chimica Acta, 642(1-2):59-68
Camacho, J., Picó, J., Ferrer, A.J. Multi-Phase Analysis Framework for Handling Batch Process Data. Journal of Chemometrics, 2008, 22:632-643.
Camacho, J., Picó, J., Ferrer, A.J. Bilinear Modelling of Batch Processes. Part II: A comparison of PLS soft-sensors. Journal of Chemometrics, 2008, 22(10):533-547.
Camacho, J., Picó, J., Ferrer, A.J. Bilinear Modelling of Batch Processes. Part I: Theoretical Discussion. Journal of Chemometrics, 2008, 22(5): 299-308.
Camacho, J., Picó, J., Ferrer, A.J. Self-tuning run to run optimization of fed-batch processes using unfold-PLS. AIChE Journal, 2007, 53(7): 1789-1804.
Camacho, J., Picó, J. Online Monitoring of Batch Processes using Multi-Phase Principal Component Analysis. Journal of Process Control, 2006, 10 (16): 1021-1035.
Camacho, J., Picó, J. Multi-phase principal component analysis for batch processes modelling. Chemometrics and Intelligent Laboratory Systems, 2006, 81(2): 127-136.
Camacho, J., Morillas, S., Latorre, P. Efficient impulsive noise suppression based on statistical confidence limits. Journal of Imaging Science and Technology, 2006, 50(5), 427 - 436.
Camacho, J., Ferrer, A.J. Monitorización de procesos por lotes mediante pca multifase. Revista Iberoamericana de Automática e Informática Industrial, 2006, 3 (3): 78-91.
