High quality raw material for IVD manufacturing industry

Recombinant antigen K39 for Leishmania infantum

RekomVet
Leishmania infantum

The canine leishmaniosis is a vector-borne disease caused by the intracellular protozoan parasites of the genus Leishmania. Although it has been demonstrated that dogs can be infected by at least twelve different species of Leishmania, the most important etiological agent of leishmaniosis is Leishmania infantum (Leishmania chagasi in Central and South America), which is the main cause of visceral and cutaneous leishmaniosis in dogs and humans in the south of Europe, near East, Africa and Central and South America. The dog is the specie more predisposed to suffer the infection of L. infantum and where the clinical symptoms are more aggressive. The canine leishmaniosis is spread in approximately 50 countries around the world, with especially high prevalence in countries of the Mediterranean basin and of South America.

Leishmaniosis is less known in cats than in dogs and humans. However, epidemiological studies have confirmed that feline infections are not rare, and that disease occurrence might be underestimated in endemic areas.

The protein K39 is a repetitive immunodominant epitope in a kinesin-related protein that is highly conserved among viscerotropic Leishmania species. It has been described that a rK39 ELISA is sensitive and specific for serodiagnosis of human and canine VL.

For diagnosis of the disease in dogs and cats.

View more information about Leishmaniosis.

REFERENCES
COA RAG0061 WB, DB, Indirect ELISA, positive control in direct ELISA, CLIA, lateral-flow
COA RAG0061BIOT (biotinylated) WB, DB, Capture ELISA, Double Antigen Sandwich (DAS), nanoparticles binding, plate orientation
GENE
K39
DESCRIPTION
Parasite kinesin-related antigen
PURITY
>98% in a SDS-PAGE
SHIPPING AND STORAGE CONDITIONS
Proteins will be shipped with dry ice or lyophilized. Upon arrival (if liquid), or after reconstitution (if lyophilized), they should be stored at -20ºC to -80ºC. Avoid multiple freeze/thaw cycles
STABILITY
The protein will remain stable for four years if stored frozen
SPECIFICITY
The protein is immunoreactive against seropositive individuals to Leishmaniosis
IVD
Serodiagnosis of human and animal leishmaniosis
RECOMMENDED ANTIGEN PAIRS:
CAPTURE: RAG0061
DETECTION: RAG0061BIOT
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Also avaliable for detection of Leishmaniosis in humans

FOR RESEARCH AND COMERCIAL USE IVD ONLY (*)

(*) Our antigens are provided for research and commercial use in vitro: not for human in vivo or therapeutic use. For more information about the general features of our antigens, you can visit here.

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