Rekom Biotech offers bioallergens, a new range of validated and high quality biomarkers intended for in vitro diagnosis of type I allergic disorders.
A wide variety of protein allergens from our environment are proteins coming from food, dust mites, pollens from trees and grasses; and other natural products. These environmental proteins come primarily from non-pathogenic eukaryotic organisms (animals and plants) and are essentially innocuous. However, in some cases, our immune system reacts to them, unintentionally causing damage to our tissues and vital organs that occasionally generates serious systemic pathologies.
The development of recombinant allergens provides new opportunities for the improvement of the diagnosis of immunoglobulin E (IgE) mediated allergies, given that they present capacity for binding these antibodies in a comparable way to natural allergens and generally show good reactivity in in vitro diagnostic test. For this reason, recombinant allergens are of a great interest to both the research field and the development of new diagnostic test for IgE quantification in the clinical routine.
The recombinant allergens of Rekom Biotech have been evaluated by means of an external study developed by a group of prestigious allergists at the Virgen de la Macarena Hospital in Seville (Spain), using samples from positive and negative patient sera. In these tests, specific IgE has been determined by the skin prick test (SPT) and the UniCAP® test. From these assays, we obtained incidence data for each bio-marker, which we later compared with that described in the literature, obtaining a very good correlation.
The measure of circulating IgE antibodies specific for a determined allergen provides information about the patient sensitisation to this allergen. In general, low IgE levels would indicate a low probability of developing a clinical disease, while high IgE levels would show a high correlation of developing disease.
Through an adequate diagnostic test incorporating our biomarkers, it would be possible to determine the allergen to which the patient is reacting and the levels of specific IgE to this allergen. This quantification will allow to predict more accurately the chance of the patient developing a disease, and thus the need for appropriate treatment.
For more information about the general features of our biomarkers, you can visit here.
|Animal||Cat (Felis domesticus)||Fel d 1||RAL0023||Uteroglobin (chain 1)|
|Dog (Canis familiaris)||Can f 1||RAL0016||Lipocalin|
|Dog urine (Canis familiaris)||Can f 5||RAL0014||Arginine esterase, prostatic kallikrein|
|Domestic Horse (Equus caballus)||Equ c 1||RAL0007||Lipocalin|
|Dust mites||American house dust mite (Dermatophagoides farinae)||Der f 2||RAL0013||NPC2 family|
|European house dust mite (Dermatophagoides pteronyssinus)||Der p 10||RAL0015||Tropomyosin|
|Storage mite (Lepidoglyphus destructor)||Lep d 2||RAL0008||NPC2 family|
|European white birch (Betula verrucosa)||Bet v 1||RAL0011||Pathogenesis-related protein (PR-10)|
|Bet v 4||RAL0009||Polcalcin|
|London plane tree (Platanus acerifolia)||Pla a 1||RAL0019||Invertase inhibitor|
|Pla a 3||RAL0021||Non-specific lipid transfer protein type 1 (LTP)|
|Mugwort pollen (Artemisia vulgaris)||Art v 1||RAL0005||Defensin-like protein|
|Art v 3||RAL0006||Non-specific lipid transfer protein type 1 (LTP)|
|Olive tree (Olea europaea)||Ole e 1||RAL0012||Proteins similar to Ole e 1|
|Ole e 2||RAL0010||Profilin|
|Ole e 5||RAL0047||Superoxide dismutase [Cu-Zn]|
|Pellitory-of-the-Wall (Parietaria judaica)||Par j 2||RAL0020||Phospholipid transfer protein (LTP)|
|Russian thistle (Salsola kali)||Sal k 1||RAL0018||Pectin methylesterase|
|Timothy grass pollen (Phleum pratense)||Phl p 1||RAL0001||Beta-expansin|
|Phl p 12||RAL0004||Profilin|
|Phl p 5a||RAL0003
|Phl p 5b||RAL0017||Unknown|
|Phl p 7||RAL0002||Polcalcin|
|Alternaria plant rot fungus (Alternaria alternata)||Alt a 1||RAL0025||Unknown|
|Cereal||Wheat (Triticum aestivum)||Tri a 19||RAL0053
|Omega-5 gliadin, seed storage protein|
|Fish||Baltic cod (Gadus callarias)||Gad c 1||RAL0035||Beta-parvalbumin|
|Milk||Caw milk (Bos domesticus)||αS1-casein||RAL0027||Casein|