High quality raw material for IVD manufacturing industry

Recombinant antigen KMP11 for Leishmania infantum

RekomVet
Leishmania infantum

The canine leishmaniosis is a vector-borne disease caused by the intracellular protozoan parasites of the genus Leishmania. Although it has been demonstrated that dogs can be infected by at least twelve different species of Leishmania, the most important etiological agent of leishmaniosis is Leishmania infantum (Leishmania chagasi in Central and South America), which is the main cause of visceral and cutaneous leishmaniosis in dogs and humans in the south of Europe, near East, Africa and Central and South America. The dog is the specie more predisposed to suffer the infection of L. infantum and where the clinical symptoms are more aggressive. The canine leishmaniosis is spread in approximately 50 countries around the world, with especially high prevalence in countries of the Mediterranean basin and of South America.

The protein KMP11 is a kinetoplastid membrane protein of 11 kDa. It has been described that the mayority of individuals with Leishmania infection without disease did not have antibodies to KMP11. Therefore serological tests with this recombinant antigen may be helpful as tools to determine therapeutic responses for VL, being the detection of antibodies to KMP11 helpful to differentiate subclinical Leishmania infection from active VL.

For diagnosis of the disease in dogs.

View more information about Leishmaniosis.

REFERENCES
RAG0038 WB, DB, Indirect ELISA, positive control in direct ELISA, lateral-flow
GENE
KMP11
DESCRIPTION
Kinetoplastid membrane antigen of 11 kDa
PURITY
>98% in a SDS-PAGE
SHIPPING AND STORAGE CONDITIONS
Proteins will be shipped with dry ice or lyophilized. Upon arrival (if liquid), or after reconstitution (if lyophilized), they should be stored at -20ºC to -80ºC. Avoid multiple freeze/thaw cycles
STABILITY
The protein will remain stable for four years if stored frozen
SPECIFICITY
The protein is immunoreactive against seropositive individuals to Leishmaniosis
IVD
Serodiagnosis of human and animal leishmaniosis
PROMOTIONAL MATERIAL
RELATED PRODUCTS
K39

FOR RESEARCH ANDCOMERCIAL USE IVD ONLY (*)

(*) Our biomarkers are provided for research and commercial use in vitro: not for human in vivo or therapeutic use. For more information about the general features of our biomarkers, you can visit here.

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