Recombinant antigen p35 (GRA8) for Toxoplasma gondii

Toxoplasmosis is a disease caused by the parasite Toxoplasma gondii which is one of the most common parasitic diseases and infects nearly all warm-blooded animals, including pets and humans. Although cats are a necessary part of the life cycle of T. gondii, the parasite rarely causes clinical disease in them. While T. gondii seldomly causes significant symptoms in healthy adults either, the Center for Disease Control and Prevention (CDC) has identified toxoplasmosis as one of five neglected parasitic infections of people due to its high prevalence. Therefore, diagnosis of toxoplasmosis is useful for human and animal health to control its spread. Several techniques are employed for the diagnosis in feline and canine population. One example is the serological detection of T. gondi, which has been described for pigs, goats, dogs, and cats.

p35 (GRA8), a 35 kDa protein, has been described as a marker of acute infection able to differentiate acute from chronic infection. There are three secretory organs present in Toxoplasma gondii cytoplasm, as the dense granules. Dense granule antigens (GRA), secreted in abundance are highly immunodominant and induce strong antibody response.

For diagnosis of the disease in birds and mammals, mainly cats.

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