Chimeras: multi-epitope antigens

9/9/2019

Chimera

Figure 1. Chimeras

At Rekom Biotech, we have specialized in the design and production of next-generation antigens: chimeras or antigens composed of multiple epitopes, which have improved their antigenic properties, such as sensitivity and specificity. Furthermore, one main advantage of the multi-epitope chimeric antigens is avoiding the use of protein mixtures in your assay. The limited number of binding sites and the different affinities of proteins for these sites could result in reproducibility issues.

EPITOPE ANALYSIS

Epitope analysis

SEQUENCE ANALYSIS

Sequence analysis

3D STUDIES

3D Studies

Rekom Biotech chimeras

DISEASE/ALLERGY NAME REFERENCES DESCRIPTION

Chagas caused by Trypanosoma cruzi
Human infectious diseases
Animal infectious diseases

ChimChagas1
RAG0093 (chimera) Top product (Satisfaction guarantee)
Recombinant chimeric antigen for Chagas detection
ChimChagas2
RAG0094 (chimera) Top product (Satisfaction guarantee)
Recombinant chimeric antigen for Chagas detection
ChimChagas3
RAG0096 (chimera) Top product (Satisfaction guarantee)
RAG0096BIOT (biotinylated)
Recombinant chimeric antigen for Chagas detection

Cytomegalovirus infection (CMV)
Human infectious diseases

ChimCMV1
RAG0109 (chimera) Top product (Satisfaction guarantee)
RAG0109BIOT (biotinylated)
Recombinant chimeric antigen which contains several antigenic determinants for CMV
ChimCMV2
RAG0110 (chimera)
RAG0110BIOT (biotinylated)
Recombinant chimeric antigen for CMV detection

Dirofilariasis caused by Dirofilaria immitis
Animal infectious diseases

ChimDiT33
RAG0014 (chimera) New
Recombinant quimeric antigen for Dirofilaria immitis

Lyme borreliosis (or Lyme disease)
Human infectious diseases
Animal infectious diseases

ChimLyme
RAG0027 (B. burgdorferi, chimera)
Recombinant chimeric antigen for Borrelia burgdorferi

Syphilis caused by Treponema pallidum
Human infectious diseases

ChimSyphilis1
RAG0046 (chimera)
RAG0046BIOT (biotinylated)
Recombinant chimeric antigen for Treponema pallidum
ChimSyphilis2
RAG0064 (chimera)
RAG0064BIOT (biotinylated)
Recombinant chimeric antigen for Treponema pallidum

Toxoplasmosis caused by Toxoplasma gondii
Human infectious diseases
Animal infectious diseases

ChimToxo1
RAG0058 (chimera)
Recombinant chimeric antigen ChimToxo1 for toxoplasmosis detection (SAG1 and GRA8)

Tuberculosis (TB) caused by Mycobacterium tuberculosis (Koch's bacillus)
Human infectious diseases
Animal infectious diseases

CFP10:ESAT6
RAG0060 (chimera)
Recombinant chimeric antigen formed by the proteins CFP10 and ESAT6

Written by Ana Camacho.