GRA7 is an excretory Neospora caninum dense granule antigen and a highly immunogenic protein of the parasite. Although GRA proteins appear to be related to intracellular parasite development, previous studies revealed that NcGRA7 might be involved in the initial host cell invasion process of N. caninum. Some published studies showed high specificity and intense signal conferred by monoclonal Ab produced against NcGRA7, which render them as strong candidates for use in developing a competitive ELISA for diagnosis of N. caninum infection. This technique would be especially useful in dogs, for which current serological techniques lack the sensitivity and specificity of those used in bovines (Silva et al. 2007, Ghalmi et al. 2009).
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