p44 is the immunodominant, most abundant outer membrane protein of Anaplasma phagocytophilum, an obligate intracellular bacteria that causes a tick-borne zoonosis termed human granulocytic anaplasmosis (HGA), the most common tick transmitted disease after borreliosis. The immunodominant polymorphic 44-kDa major surface proteins of A. phagocytophilum, is a member of the p44/msp2 multigene family and are encoded by more than 80 p44 paralogs dispersed throughout the genome. The 44-kDa-protein-specific antibodies play a role in immunity against infection. This immunogenic antigen is therefore important in pathogenesis and laboratory diagnosis.
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