gp40 -is a transmembrane glycoprotein responsible for viral membrane fusion with the host cell membrane. The gp40 subunit contains different functional regions in its ectodomain: the fusion peptide (FP), heptad repeat 1 (HR1), HR2, and the transmembrane region. This protein is very similar to gp41 from HIV. The sequence of gp40 contains four functional regions, as follows: the N-terminal fusion peptide (which is thought to insert into the host cell membrane) is followed by an ectodomain, a transmembrane region and a cytoplasmic domain.
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