Tuberculosis (TB) is a respiratory infection caused by the bacteria Mycobacterium tuberculosis, also known as Koch's bacillus. It affects humans and animals, mainly cattle. The transmission occurs through the air, when the infected patient speaks, sneezes or coughs. However, it is also possible, although less common, for a person to get sick from eating contaminated products, such as milk or meat. The most common symptoms are severe cough, weight loss, spitting up blood or mucus, weakness, fever and chills. If not treated properly, it can be fatal. Not all patients infected by the bacteria get sick. It is what is known as latent tuberculosis (LTBI), which, without treatment, can lead to the disease. These patients do not transmit the disease. The treatment consists of antibiotics, and as a prevention it is recommended to avoid contact with infected people, use medications in high-risk cases and maintain good living conditions. The diagnosis of tuberculosis can be made through a blood test to detect the bacteria or antibodies against it, or through a tuberculin skin test.
Tuberculosis is the most prevalent infectious disease in the world. It is the leading cause of death among people infected with HIV, and among those related to antimicrobial resistance. It is estimated that, thanks to global efforts against tuberculosis, 66 million people have saved their lives since 2000. However, COVID-19 has reversed this data and, for the first time in more than 10 years, in 2020 deaths from tuberculosis increased again (of 9.9 million patients in 2020, 1.5 million died). Without treatment, an average of 1 in 10 people with latent TB infection will develop TB disease in the future. It is estimated that more than 80% of people who develop tuberculosis have had an untreated latent tuberculosis infection.
Although infection in cattle is controlled in most countries, complete elimination of the disease is complicated by persistent infection of wildlife. The highest prevalence of bovine tuberculosis is in Africa and parts of Asia, although the disease is also found in countries in Europe and the Americas.
At Rekom Biotech, we desing and manufacture IVD reagents for diagnosis of Tuberculosis (TB). Do not hesitate to contact us!
Generation of the antibody with our own immunogen in an animal model.
Purification of the serum obtained by affinity chromatography.
Validation and full quality control.