Recombinant allergens for IVD of allergies
Rekom Biotech offers recombinant allergens for in vitro diagnosis of allergies (type I allergic disorders).
A wide variety of protean allergens from our environment are proteins coming from food, mites, pollens from trees and grasses; and other natural products. These environmental proteins come primarily from non-pathogenic eukaryotic organisms (animals and plants) and are essentially innocuous. However, in some cases, our immune system reacts to them, unintentionally causing damage to our tissues and vital organs that occasionally generates serious systemic pathologies.
The development of recombinant allergens provides new opportunities for the improvement of the diagnosis of immunoglobulin E (IgE) mediated allergies, given that they present capacity for binding these antibodies in a comparable way to natural allergens and generally show good reactivity in in vitro diagnostic tests. For this reason, recombinant allergens are of a great interest to both the research field and the development of new diagnostic test for IgE quantification in the clinical routine. The measure of circulating IgE antibodies specific for a determined allergen provides information about the patient sensitisation to this allergen. In general, low IgE levels would indicate a low probability of developing a clinical disease, while high IgE levels would show a high correlation of developing disease.
Our recombinant allergens have been evaluated by means of an external study developed by a group of prestigious allergists at the Virgen de la Macarena Hospital in Seville (Spain), using samples from positive and negative patient sera. In these tests, specific IgE has been determined by the skin prick test (SPT) and the UniCAP® test. From these assays, we obtained incidence data for each antigen, which we later compared with that described in the literature, obtaining a very good correlation. Through an adequate diagnostic test incorporating our proteins, it would be possible to determine the allergen to which the patient is reacting and the levels of specific IgE to this allergen. This quantification will allow to predict more accurately the chance of the patient developing an allergy, and thus the need for appropriate treatment.
We design and produce recombinant allergens for allergies caused by food, domestic animals and indoor allergens, mold and pollen. Take a look at our portfolio!
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If you do not find what you are looking for, check our pipeline. You can also request our custom-made recombinant proteins service.
Recombinant allergens for the diagnosis of allergies caused by Domestic animals and Indoor
Recombinant allergens for the diagnosis of allergies caused by Food
Recombinant allergens for the diagnosis of allergies caused by Mold
| SPECIES | NAME | CAT NUMBER | DESCRIPTION | DETAILS |
|---|---|---|---|---|
| Alternaria alternata (Plant rot fungus) | Alt a 1 |
RAL0025
|
Unknown |