Recombinant proteins for IVD of allergies

Rekom Biotech also offers recombinant proteins for in vitro diagnosis of allergies (type I allergic disorders).

A wide variety of protean allergens from our environment are proteins coming from food, dust mites, pollens from trees and grasses; and other natural products. These environmental proteins come primarily from non-pathogenic eukaryotic organisms (animals and plants) and are essentially innocuous. However, in some cases, our immune system reacts to them, unintentionally causing damage to our tissues and vital organs that occasionally generates serious systemic pathologies.

The development of recombinant allergens provides new opportunities for the improvement of the diagnosis of immunoglobulin E (IgE) mediated allergies, given that they present capacity for binding these antibodies in a comparable way to natural allergens and generally show good reactivity in in vitro diagnostic test. For this reason, recombinant allergens are of a great interest to both the research field and the development of new diagnostic test for IgE quantification in the clinical routine. The measure of circulating IgE antibodies specific for a determined allergen provides information about the patient sensitisation to this allergen. In general, low IgE levels would indicate a low probability of developing a clinical disease, while high IgE levels would show a high correlation of developing disease.

Our recombinant allergens have been evaluated by means of an external study developed by a group of prestigious allergists at the Virgen de la Macarena Hospital in Seville (Spain), using samples from positive and negative patient sera. In these tests, specific IgE has been determined by the skin prick test (SPT) and the UniCAP® test. From these assays, we obtained incidence data for each antigen, which we later compared with that described in the literature, obtaining a very good correlation. Through an adequate diagnostic test incorporating our proteins, it would be possible to determine the allergen to which the patient is reacting and the levels of specific IgE to this allergen. This quantification will allow to predict more accurately the chance of the patient developing an allergy, and thus the need for appropriate treatment.

We design and produce recombinant proteins for allergies caused by food, domestic animals and indoor allergens, mold and pollen. Take a look at our portfolio!

If you prefer, search your recombinant protein by:

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Bioallergens

If you do not find what you are looking for, check our pipeline.

Proteins for the diagnosis of allergies caused by Domestic animals and Indoor

This group includes the allergens present in the feces of dust mites and cockroaches; and in animal dander.

TYPE SPECIES NAME REFERENCES DESCRIPTION DETAILS
Animal Canis familiaris (Dog epithelium) Can f 1
RAL0016
RAL0026
Lipocalin
Canis familiaris (Dog urine) Can f 5
RAL0014 Top product (Satisfaction guarantee)
Arginine esterase, prostatic kallikrein
Equus caballus (Horse epithelium) Equ c 1
RAL0007
RAL0022
Lipocalin
Felis domesticus (Cat epithelium) Fel d 1
RAL0023 Top product (Satisfaction guarantee)
Uteroglobin (chain 1)
Dust mites Dermatophagoides farinae (American house dust mite) Der f 2
RAL0013
NPC2 family
Dermatophagoides pteronyssinus (European house dust mite) Der p 10
RAL0015
Tropomyosin
Lepidoglyphus destructor (Storage mite) Lep d 2
RAL0008
NPC2 family

Proteins for the diagnosis of allergies caused by Food

Sometimes, an adverse health effect arise in certain people who are exposed to a given food, arising from a specific immune response to it. The most common form of immune-mediated adverse reactions to foods is type I reactions, which is characterized by the development of IgE against food allergens. This food allergy affects approximately 3% of the population.

These food allergies have increased considerably in the last thirty years due to a major change in our eating habits. For example, an increasingly frequent consumption of food of exotic nature, new ways of preparing food, early diversification of food in babies and the presence in food of new proteins that enhance taste and change colour and consistency of food.

TYPE SPECIES NAME REFERENCES DESCRIPTION DETAILS
Cereal Triticum aestivum (Wheat) Tri a 19
RAL0053
RAL0053BIOT (biotinylated)
Omega-5 gliadin, seed storage protein
Egg Gallus domesticus (Chicken egg) Gal d 1
RAL0033
Ovomucoid
Fish Gadus callarias (Baltic cod) Gad c 1
RAL0035
Beta-parvalbumin
Milk Bos domesticus (Cow milk) αS1-casein
RAL0027
Casein
β-casein
RAL0029
Casein
β-lactoglobulin
RAL0032
Beta-lactoglobulin
Rosaceous Malus domestica (Apple) Mal d 3
RAL0039
Non-specific lipid transfer protein type 1 (nsLTP1)

Proteins for the diagnosis of allergies caused by Mold

This group contains allergens present in outdoor molds, which live on the trunks and leaves of the trees, and indoor molds, located in warm and humid places such as bathrooms and kitchens.

SPECIES NAME REFERENCES DESCRIPTION DETAILS
Alternaria alternata (Plant rot fungus) Alt a 1
RAL0025
Unknown

Proteins for the diagnosis of allergies caused by Pollen

Pollen is a fine yellowish powder that is transported from one plant to another by wind, birds, insects and other animals. The spread of pollen helps to fertilize plants and causes innumerable allergies throughout the year in many people. This group contains pollens from trees, grasses and weeds.

SPECIES NAME REFERENCES DESCRIPTION DETAILS
Artemisia vulgaris (Mugwort pollen) Art v 1
RAL0005
Defensin-like protein
Art v 3
RAL0006
RAL0048
Non-specific lipid transfer protein type 1 (LTP)
Betula verrucosa (White birch pollen) Bet v 1
RAL0011
Pathogenesis-related protein (PR-10)
Bet v 4
RAL0009
Polcalcin
Olea europaea (Olive tree pollen) Ole e 1
RAL0012 Top product (Satisfaction guarantee)
Proteins similar to Ole e 1
Ole e 2
RAL0010
Profilin
Ole e 5
RAL0047
Superoxide dismutase [Cu-Zn]
Parietaria judaica (Pellitory of the wall pollen) Par j 2
RAL0020
Phospholipid transfer protein (LTP)
Phleum pratense (Timothy grass pollen) Phl p 1
RAL0001 Top product (Satisfaction guarantee)
Beta-expansin
Phl p 12
RAL0004
Profilin
Phl p 5a
RAL0003
RAL0003BIOT (biotinylated)
Unknown
Phl p 5b
RAL0017
Unknown
Phl p 7
RAL0002
Polcalcin
Platanus acerifolia (London plane tree pollen) Pla a 1
RAL0019
Invertase inhibitor
Pla a 3
RAL0021
Non-specific lipid transfer protein type 1 (LTP)
Salsola kali (Russian thistle pollen) Sal k 1
RAL0018
Pectin methylesterase