Recombinant proteins for IVD of allergies
Rekom Biotech also offers recombinant proteins for in vitro diagnosis of allergies (type I allergic disorders).
A wide variety of protean allergens from our environment are proteins coming from food, dust mites, pollens from trees and grasses; and other natural products. These environmental proteins come primarily from non-pathogenic eukaryotic organisms (animals and plants) and are essentially innocuous. However, in some cases, our immune system reacts to them, unintentionally causing damage to our tissues and vital organs that occasionally generates serious systemic pathologies.
The development of recombinant allergens provides new opportunities for the improvement of the diagnosis of immunoglobulin E (IgE) mediated allergies, given that they present capacity for binding these antibodies in a comparable way to natural allergens and generally show good reactivity in in vitro diagnostic test. For this reason, recombinant allergens are of a great interest to both the research field and the development of new diagnostic test for IgE quantification in the clinical routine. The measure of circulating IgE antibodies specific for a determined allergen provides information about the patient sensitisation to this allergen. In general, low IgE levels would indicate a low probability of developing a clinical disease, while high IgE levels would show a high correlation of developing disease.
Our recombinant allergens have been evaluated by means of an external study developed by a group of prestigious allergists at the Virgen de la Macarena Hospital in Seville (Spain), using samples from positive and negative patient sera. In these tests, specific IgE has been determined by the skin prick test (SPT) and the UniCAP® test. From these assays, we obtained incidence data for each antigen, which we later compared with that described in the literature, obtaining a very good correlation. Through an adequate diagnostic test incorporating our proteins, it would be possible to determine the allergen to which the patient is reacting and the levels of specific IgE to this allergen. This quantification will allow to predict more accurately the chance of the patient developing an allergy, and thus the need for appropriate treatment.
We design and produce recombinant proteins for allergies caused by food, domestic animals and indoor allergens, mold and pollen. Take a look at our portfolio!
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Proteins for the diagnosis of allergies caused by Domestic animals and Indoor
This group includes the allergens present in the feces of dust mites and cockroaches; and in animal dander.
Proteins for the diagnosis of allergies caused by Food
Sometimes, an adverse health effect arise in certain people who are exposed to a given food, arising from a specific immune response to it. The most common form of immune-mediated adverse reactions to foods is type I reactions, which is characterized by the development of IgE against food allergens. This food allergy affects approximately 3% of the population.
These food allergies have increased considerably in the last thirty years due to a major change in our eating habits. For example, an increasingly frequent consumption of food of exotic nature, new ways of preparing food, early diversification of food in babies and the presence in food of new proteins that enhance taste and change colour and consistency of food.
Proteins for the diagnosis of allergies caused by Mold
This group contains allergens present in outdoor molds, which live on the trunks and leaves of the trees, and indoor molds, located in warm and humid places such as bathrooms and kitchens.
| SPECIES | NAME | CAT NUMBER | DESCRIPTION | DETAILS |
|---|---|---|---|---|
| Alternaria alternata (Plant rot fungus) | Alt a 1 |
RAL0025
|
Unknown |
Proteins for the diagnosis of allergies caused by Pollen
Pollen is a fine yellowish powder that is transported from one plant to another by wind, birds, insects and other animals. The spread of pollen helps to fertilize plants and causes innumerable allergies throughout the year in many people. This group contains pollens from trees, grasses and weeds.