Recombinant antigen HBeAg for Hepatitis B virus (HBV)

Hepatitis B virus (HBV)

The “e” antigen (HBeAg) is formed by the pre-core protein ORF that will result in the secretion of a heterogeneous population of polypeptides that display “e” antigenicity.

During the replication cycle of hepatitis B virus (HBV), three major viral antigens, termed core antigen, surface antigen and “e” antigen, are produced. The core antigen is a conformational antigenic determinant displayed by the viral core protein, and the surface antigen represents the antigenic determinants displayed by the three viral envelope proteins. It has been used as the synonym for HBV envelope proteins. The core protein expressed this way will self assemble into core particles that display core antigenicity. In contrast, the expression of the pre-core protein ORF will result in the secretion of a heterogeneous population of polypeptides that display “e” antigenicity.

While HBeAg antigen has no demonstrated role in the viral replication cycle, the antigen has long been a key clinical marker for viral replication, infectivity, disease severity, and response to treatment.

More information about Hepatitis B.

or
Name
HBeAg
Description
HBV e antigen that comprises the 10 aa pre-core sequence plus the 149-residue assembly core domain
Gene
pre-core sequence plus the core domain
Purity
> 95% by observation on SDS-PAGE electrophoresis
References
SKU Source Applications In-house validation Details
RAG0062 New E. coli WB, DB, IE, DE, CLIA, LF ELISA Example of a certificate of analysis Material Safety Data Sheet
WB: Western Blot | DB: Dot Blot | IE: Indirect ELISA | DE: positive control in Direct ELISA | CLIA: Chemiluminescent immunoassay | LF: Lateral-Flow | CE: Capture ELISA | DAS: Double Antigen Sandwich ELISA | NP: Nanoparticles binding | PO: Plate orientation | COA: Certificate of analysis | SDS: Material Safety Data Sheet
Formats
Liquid protein solution or dry powder (lyophilised) in vials of 0.1 mg, 1 mg and bulk
Related products

For research and comercial use IVD only (*)

(*) Our IVD reagents are provided for research and commercial use in vitro: not for human in vivo or therapeutic use. You can get more information about the general features and about the shipping, storage, defrost, manipulation and stability of all of our reagents. In addition, we follow a rigorous quality control for each lot.

Bact to list of Proteins for human infectious diseases