Hepatitis B is a serious infection that affects the liver, and it is caused by the hepatitis B virus (HBV). The transmission occurs through contact with blood, blood transfusion, semen or other fluids of the infected person, and can be passed from mother to child during childbirth. Symptoms can range from mild to severe, appearing one to four months after infection. The most common are abdominal pain, dark urine, fever, joint pain, loss of appetite, nausea, vomiting, weakness, and jaundice. However, it can lead to chronic infection, increasing the risk of liver failure, liver cancer, cirrhosis or liver scarring. Treatment consists of immune globulin injections and vaccination right after exposure to the virus. In the acute phase of the disease there is no treatment, except rest and good nutrition, sometimes requiring hospitalization to prevent complications. The chronic phase is treated with antivirals, interferon injections, or even liver transplantation. As a prevention, vaccination, safe sex and avoid direct contact with the blood of other people are recommended. The diagnosis of hepatitis B is made through blood tests to detect the virus or antibodies against it, liver ultrasound and liver biopsy. In the early phase, being asymptomatic, the disease is not usually detected. It is in the most advanced stages when it is diagnosed, having a worse prognosis, both in terms of survival and quality of life. Therefore, an early diagnosis is very important to stop the disease.
Hepatitis B and C, the most common, cause 3 million infections and 1.1 million deaths per year. It is estimated that only 10% of people infected with hepatitis B have been diagnosed and 22% of these are receiving treatment. The Western Pacific (6.2%) and Africa (6%) have the highest prevalence rates, followed by the Eastern Mediterranean (3.3%), South-East Asia (2%), Europe (1.6%) and America (0.7%).
At Rekom Biotech, we desing and manufacture IVD reagents for diagnosis of Hepatitis B. If you do not find what you are looking for, you can request our custom-made recombinant proteins/antibodies service. Do not hesitate to contact us!
|Hepatitis B virus core antigen assembled as capsid-like particles|
|HBV e antigen that comprises the 10 aa pre-core sequence plus the 149-residue assembly core domain|
|Polyclonal antibody against HBcAg for Hepatitis B virus (HBV)|
Protein design from scratch, always trying to improve its antigenic capacity.
Search for the best DNA construction according to the design phase.
Selection of the best expression system for the protein.
Process adjustments to achieve an optimal seed, and the process to isolate our protein from the obtained seed.
Validation and full quality control.