CCD
Immunoassay blocker to eliminate cross-reactive anti-carbohydrate antibodies

This blocker it should be used to avoid interference in an IgG/IgM indirect assay when a recombinant antigen produced in Pichia pastoris is used for Ab detection in mammalian sera. Occasionally, the anti-cross-reactive carbohydrate determinants (anti-CCD) antibodies are present in human and animal sera due to previous immunization against pathogenic fungi such as Candida albicans, the most common cause of opportunistic fungal diseases in humans. These pathogenic fungi share the same type of glycosylation with Pichia pastoris. Therefore, these anti-CCDs should be pre-absorbed to avoid false positive results.

References of Immunoassay blocker to eliminate cross-reactive anti-carbohydrate (CCD) antibodies

Folletos

• Rekom Biotech catalogue
• Inmunoassay blocker for proteins made in Pichia pastoris

Videos

• How to reconsitute lyophizated vials
• How to use the inmunoassay blocker for anti-cross-reactive carbohydrate determinants (CCD) antibodies

Evaluaciones

• Nucleoprotein and spike glycoprotein, a combination of two quite different antigens for COVID-19 in vitro diagnostic

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