CagA(Dom I)
for Helicobacter pylori

The CagA antigen (Cytotoxin-associated gene A) is a protein produced by the bacterium Helicobacter pylori (H. pylori), a pathogen known to cause various gastric diseases such as gastritis, peptic ulcers, and gastric cancer. Not all H. pylori strains carry the cagA gene. Strains that possess it are typically associated with increased disease severity and a higher risk of developing severe conditions, including peptic ulcers and gastric cancer.

The first 200 amino acids of CagA, comprising Domain I, are sufficient for membrane binding, suggesting that the N-terminal domain is crucial for CagA localization within the phospholipid bilayer or to membrane-bound receptors. Furthermore, this domain mitigates the junctional and polarity defects induced by the CagA C-terminus and is believed to function as an intrinsic inhibitory domain that reduces the protein's carcinogenic potential

References of Recombinant antigen CagA(Dom I)

Folletos

• Rekom Biotech catalogue
• Recombinant proteins for in vitro diagnosis of human infectious diseases

Videos

• How to reconsitute lyophizated vials